Any successful use cases of Blockchain that does not involve speculation

The technology underlying blockhains like Ethereum is pretty impressive. To be able to have a distributed ledger without any central authority enforcing its integrity is pretty amazing.

But so far so good, looking at the application of this technology, it is clear the only ways it has gained any mainstream usage are those usage that involves speculation.

One can safely say all coins (shit ones and non-shit ones), get attention because of the get rich quick allure (aka speculation)

The current form of NFTs are nothing more but speculation.

DeFI I think seems to provide some form of real value that is not really about speculating.

So my question is this, anyone knows of any real live, mainstream application of Blockchain that does not involve speculation?

Any business application in industry or enterprise for instance?

I cant seem to find any, so I would appreciate some pointers.