What's a relatively safe Operating System to do crypto transactions on?

There is certainly a grounded sense of worry, about Windows not being be a very safe option, considering the cyber attacks going on lately. Would an instanced operating system in Virtual Box, be a safer alternative? What about an option like Tails OS? is that a better way for doing crypto transactions? Or you have noticed there is a systems conflict between the effort for anonymity and the financial platforms themselves? Has any of you fellas out there had any experience with alternative Operating Systems for managing and performing your transactions? Your feedback would be greatly appreciated. Thank you very much in advance.